archetype (adl_version=1.4; uid=f7f8c6bb-02e3-4045-8673-16e305334509)
	openEHR-EHR-OBSERVATION.iss.v0

concept
	[at0000]	-- International Staging System for Multiple Myeloma (ISS)
language
	original_language = <[ISO_639-1::en]>
description
	original_author = <
		["name"] = <"Maryam Razavi">
		["organisation"] = <"Cambio CDS">
		["email"] = <"maryam.razavi@cambio.se">
		["date"] = <"2020-12-22">
	>
	details = <
		["en"] = <
			language = <[ISO_639-1::en]>
			purpose = <"To record the results for each component parameter and the resulting ISS stage.">
			use = <"Use to record the results for each component parameter and the resulting ISS stage.">
			keywords = <"albumin", "multiple", "myeloma", "staging", "system">
			misuse = <"Not to be used to record the results for the Revised Multiple Myeloma International Staging System (R-ISS) - use the specialisation of this archetype for this purpose.">
			copyright = <"© Cambio CDS, openEHR Foundation">
		>
	>
	lifecycle_state = <"in_development">
	other_contributors = <>
	other_details = <
		["licence"] = <"This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/.">
		["custodian_organisation"] = <"openEHR Foundation">
		["references"] = <"Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975 Sep;36(3):842-54. doi: 10.1002/1097-0142(197509)36:3<842::aid-cncr2820360303>3.0.co;2-u. PMID: 1182674.

Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J. International staging system for multiple myeloma. J Clin Oncol. 2005 May 20;23(15):3412-20. doi: 10.1200/JCO.2005.04.242. Epub 2005 Apr 4. Erratum in: J Clin Oncol. 2005 Sep 1;23(25):6281. Harousseau, Jean-Luc [corrected to Avet-Loiseau, Herve]. PMID: 15809451.">
		["current_contact"] = <"maryam.razavi@cambio.se">
		["original_namespace"] = <"org.openehr">
		["original_publisher"] = <"openEHR Foundation">
		["custodian_namespace"] = <"org.openehr">
		["MD5-CAM-1.0.1"] = <"AE16B20A4F7EB81C2C3AD2760ECAD37B">
		["build_uid"] = <"83703169-7c26-43c8-96df-e0a724bfe1e3">
		["revision"] = <"0.0.1-alpha">
	>

definition
	OBSERVATION[at0000] matches {    -- International Staging System for Multiple Myeloma (ISS)
		data matches {
			HISTORY[at0001] matches {    -- Event Series
				events cardinality matches {1..*; unordered} matches {
					EVENT[at0002] occurrences matches {0..1} matches {    -- Any event
						data matches {
							ITEM_TREE[at0003] matches {    -- Tree
								items cardinality matches {0..*; unordered} matches {
									ELEMENT[at0004] occurrences matches {0..1} matches {    -- Serum β2 microglobulin
										value matches {
											DV_CODED_TEXT matches {
												defining_code matches {
													[local::
													at0005,    -- <3.5 mg/L
													at0006,    -- 3.5-5.4 mg/L
													at0007]    -- >5.4 mg/L
												}
											}
										}
									}
									ELEMENT[at0008] occurrences matches {0..1} matches {    -- Serum albumin
										value matches {
											DV_CODED_TEXT matches {
												defining_code matches {
													[local::
													at0009,    -- <3.5 g/dL
													at0010]    -- ≥3.5 g/dL
												}
											}
										}
									}
									ELEMENT[at0011] occurrences matches {0..1} matches {    -- ISS stage
										value matches {
											DV_CODED_TEXT matches {
												defining_code matches {
													[local::
													at0012,    -- ISS I
													at0013,    -- ISS II
													at0014]    -- ISS III
												}
											}
										}
									}
								}
							}
						}
					}
				}
			}
		}
		protocol matches {
			ITEM_TREE[at0015] matches {    -- Item tree
				items cardinality matches {0..*; unordered} matches {
					allow_archetype CLUSTER[at0016] occurrences matches {0..*} matches {    -- Extension
						include
							archetype_id/value matches {/.*/}
					}
				}
			}
		}
	}


ontology
	term_definitions = <
		["en"] = <
			items = <
				["at0000"] = <
					text = <"International Staging System for Multiple Myeloma (ISS)">
					description = <"A staging system for classifying and stratifying patients with multiple myeloma.">
				>
				["at0001"] = <
					text = <"Event Series">
					description = <"@ internal @">
				>
				["at0002"] = <
					text = <"Any event">
					description = <"Default, unspecified point in time or interval event which may be explicitly defined in a template or at run-time.">
				>
				["at0003"] = <
					text = <"Tree">
					description = <"@ internal @">
				>
				["at0004"] = <
					text = <"Serum β2 microglobulin">
					description = <"">
				>
				["at0008"] = <
					text = <"Serum albumin">
					description = <"">
				>
				["at0011"] = <
					text = <"ISS stage">
					description = <"">
				>
				["at0012"] = <
					text = <"ISS I">
					description = <"Serum β2-microglobulin <3.5 mg/L and serum albumin ≥3.5 g/dL.">
				>
				["at0013"] = <
					text = <"ISS II">
					description = <"Not stage I or III.">
				>
				["at0014"] = <
					text = <"ISS III">
					description = <"Serum β2-microglobulin ≥5.5 mg/L.">
				>
				["at0005"] = <
					text = <"<3.5 mg/L">
					description = <"">
				>
				["at0006"] = <
					text = <"3.5-5.4 mg/L">
					description = <"">
				>
				["at0007"] = <
					text = <">5.4 mg/L">
					description = <"">
				>
				["at0009"] = <
					text = <"<3.5 g/dL">
					description = <"">
				>
				["at0010"] = <
					text = <"≥3.5 g/dL">
					description = <"">
				>
				["at0015"] = <
					text = <"Item tree">
					description = <"@ internal @">
				>
				["at0016"] = <
					text = <"Extension">
					description = <"Additional information required to extend the model with local content or to align with other reference models or formalisms.">
					comment = <"For example: local information requirements; or additional metadata to align with FHIR.">
				>
			>
		>
	>